ACRIA participated in a multicenter study of 412 patients, who gave themselves subcutaneous injections of either TH9507 or placebo once a day.

After 26 weeks, people taking TH9507 had a decrease in visceral abdominal fat (-15.2%), while those taking placebo had a slight increase (+5%). People talking TH9507 also had significant decreases in triglyceride levels and cholesterol-to-HDL ratios.

People were then assigned to one of three groups: those taking TH9507 kept taking it for 26 more weeks, or they switched to placebo, or vice versa.

People who took TH9507 for 52 weeks lost about 2.75 lbs. of trunk fat on average, whereas those who switched to placebo ended up with slightly more trunk fat than at the start. Limb fat did not change much in either group.